Tuning InAs nanowire density for HEK293 cell viability, adhesion, and morphology: perspectives for nanowire-based biosensors.
Identifieur interne : 000302 ( Main/Exploration ); précédent : 000301; suivant : 000303Tuning InAs nanowire density for HEK293 cell viability, adhesion, and morphology: perspectives for nanowire-based biosensors.
Auteurs : RBID : pubmed:24074264Abstract
Arrays of nanowires (NWs) are currently being established as vehicles for molecule delivery and electrical- and fluorescence-based platforms in the development of biosensors. It is conceivable that NW-based biosensors can be optimized through increased understanding of how the nanotopography influences the interfaced biological material. Using state-of-the-art homogenous NW arrays allow for a systematic investigation of how the broad range of NW densities used by the community influences cells. Here it is demonstrated that indium arsenide NW arrays provide a cell-promoting surface, which affects both cell division and focal adhesion up-regulation. Furthermore, a systematic variation in NW spacing affects both the detailed cell morphology and adhesion properties, where the latter can be predicted based on changes in free-energy states using the proposed theoretical model. As the NW density influences cellular parameters, such as cell size and adhesion tightness, it will be important to take NW density into consideration in the continued development of NW-based platforms for cellular applications, such as molecule delivery and electrical measurements.
DOI: 10.1021/am402070k
PubMed: 24074264
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tuning InAs nanowire density for HEK293 cell viability, adhesion, and morphology: perspectives for nanowire-based biosensors.</title><author><name sortKey="Bonde, Sara" uniqKey="Bonde S">Sara Bonde</name><affiliation wicri:level="1"><nlm:affiliation>Bionanotechnology and Nanomedicine Laboratory, Department of Chemistry and Nano-science Center, University of Copenhagen , Universitetsparken 5, DK-2100, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Bionanotechnology and Nanomedicine Laboratory, Department of Chemistry and Nano-science Center, University of Copenhagen , Universitetsparken 5, DK-2100, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Berthing, Trine" uniqKey="Berthing T">Trine Berthing</name></author><author><name sortKey="Madsen, Morten Hannibal" uniqKey="Madsen M">Morten Hannibal Madsen</name></author><author><name sortKey="Andersen, Tor Kristian" uniqKey="Andersen T">Tor Kristian Andersen</name></author><author><name sortKey="Buch M Nson, Nina" uniqKey="Buch M Nson N">Nina Buch-Månson</name></author><author><name sortKey="Guo, Lei" uniqKey="Guo L">Lei Guo</name></author><author><name sortKey="Li, Xiaomei" uniqKey="Li X">Xiaomei Li</name></author><author><name sortKey="Badique, Florent" uniqKey="Badique F">Florent Badique</name></author><author><name sortKey="Anselme, Karine" uniqKey="Anselme K">Karine Anselme</name></author><author><name sortKey="Nyg Rd, Jesper" uniqKey="Nyg Rd J">Jesper Nygård</name></author><author><name sortKey="Martinez, Karen L" uniqKey="Martinez K">Karen L Martinez</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.1021/am402070k</idno><idno type="RBID">pubmed:24074264</idno><idno type="pmid">24074264</idno><idno type="wicri:Area/Main/Corpus">000391</idno><idno type="wicri:Area/Main/Curation">000391</idno><idno type="wicri:Area/Main/Exploration">000302</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Arrays of nanowires (NWs) are currently being established as vehicles for molecule delivery and electrical- and fluorescence-based platforms in the development of biosensors. It is conceivable that NW-based biosensors can be optimized through increased understanding of how the nanotopography influences the interfaced biological material. Using state-of-the-art homogenous NW arrays allow for a systematic investigation of how the broad range of NW densities used by the community influences cells. Here it is demonstrated that indium arsenide NW arrays provide a cell-promoting surface, which affects both cell division and focal adhesion up-regulation. Furthermore, a systematic variation in NW spacing affects both the detailed cell morphology and adhesion properties, where the latter can be predicted based on changes in free-energy states using the proposed theoretical model. As the NW density influences cellular parameters, such as cell size and adhesion tightness, it will be important to take NW density into consideration in the continued development of NW-based platforms for cellular applications, such as molecule delivery and electrical measurements.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">24074264</PMID><DateCreated><Year>2013</Year><Month>11</Month><Day>13</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1944-8252</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>21</Issue><PubDate><Year>2013</Year><Month>Nov</Month><Day>13</Day></PubDate></JournalIssue><Title>ACS applied materials & interfaces</Title><ISOAbbreviation>ACS Appl Mater Interfaces</ISOAbbreviation></Journal><ArticleTitle>Tuning InAs nanowire density for HEK293 cell viability, adhesion, and morphology: perspectives for nanowire-based biosensors.</ArticleTitle><Pagination><MedlinePgn>10510-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/am402070k</ELocationID><Abstract><AbstractText>Arrays of nanowires (NWs) are currently being established as vehicles for molecule delivery and electrical- and fluorescence-based platforms in the development of biosensors. It is conceivable that NW-based biosensors can be optimized through increased understanding of how the nanotopography influences the interfaced biological material. Using state-of-the-art homogenous NW arrays allow for a systematic investigation of how the broad range of NW densities used by the community influences cells. Here it is demonstrated that indium arsenide NW arrays provide a cell-promoting surface, which affects both cell division and focal adhesion up-regulation. Furthermore, a systematic variation in NW spacing affects both the detailed cell morphology and adhesion properties, where the latter can be predicted based on changes in free-energy states using the proposed theoretical model. As the NW density influences cellular parameters, such as cell size and adhesion tightness, it will be important to take NW density into consideration in the continued development of NW-based platforms for cellular applications, such as molecule delivery and electrical measurements.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bonde</LastName><ForeName>Sara</ForeName><Initials>S</Initials><Affiliation>Bionanotechnology and Nanomedicine Laboratory, Department of Chemistry and Nano-science Center, University of Copenhagen , Universitetsparken 5, DK-2100, Copenhagen, Denmark.</Affiliation></Author><Author ValidYN="Y"><LastName>Berthing</LastName><ForeName>Trine</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Madsen</LastName><ForeName>Morten Hannibal</ForeName><Initials>MH</Initials></Author><Author ValidYN="Y"><LastName>Andersen</LastName><ForeName>Tor Kristian</ForeName><Initials>TK</Initials></Author><Author ValidYN="Y"><LastName>Buch-Månson</LastName><ForeName>Nina</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Lei</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xiaomei</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Badique</LastName><ForeName>Florent</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Anselme</LastName><ForeName>Karine</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Nygård</LastName><ForeName>Jesper</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>Karen L</ForeName><Initials>KL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>10</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Appl Mater Interfaces</MedlineTA><NlmUniqueID>101504991</NlmUniqueID><ISSNLinking>1944-8244</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>10</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>10</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1021/am402070k</ArticleId><ArticleId IdType="pubmed">24074264</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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